| Round | Date | H/A | Brk Max | Brks Over 30 | W/L | Pts | v | Pts | Away | Team | Brks Over 30 | Brk Max |
| Week 1 | 30/09/2021 | Away | | | Won | 61 | v | 49 | Lloyd, Chris (14) | Kings Club 'C' | | |
| Week 2 | 07/10/2021 | Home | | | Won | 88 | v | 55 | Sweeney, Ian (24) | Bridgewater 'A' | | |
| Week 3 | 14/10/2021 | Away | | | Won | 67 | v | 58 | McKenna, Dave (7) | Irlam Catholic | | |
| Week 4 | 21/10/2021 | Home | | | Won | 82 | v | 65 | Newton, Jon (6) | The Grange | | |
| Week 5 | 28/10/2021 | Away | | | Won | 85 | v | 62 | Stringfellow, Pete (29) | Eagle Sports | | |
| Week 7 | 11/11/2021 | Away | | | Lost | 43 | v | 79 | Horobin, Scott (5) | Woolston 'A' | | |
| Week 13 | 06/01/2022 | Home | 32 | 1 | Won | 67 | v | 63 | Cook, Dexter (2) | Monks 'A' | | |
| Week 14 | 13/01/2022 | Home | | | Lost | 65 | v | 92 | Clark, Alf (30) | Kings Club 'C' | | |
| Week 15 | 20/01/2022 | Away | | | Lost | 66 | v | 93 | Sweeney, Graham (37) | Bridgewater 'A' | | |
| Week 16 | 27/01/2022 | Home | | | Lost | 60 | v | 82 | Ward, Dave (3) | Irlam Catholic | | |
| Week 17 | 03/02/2022 | Away | | | Lost | 41 | v | 96 | Beaton, James (-17) | The Grange | 1 | 40 |
| Week 21 | 03/03/2022 | Away | | | Won | 57 | v | 47 | Whibley, James (28) | Kings Club 'A' | | |
| Week 22 | 10/03/2022 | Home | | | Lost | 73 | v | 75 | Herriot, Glen (25) | Penketh Cons 'B' | | |
| Week 23 | 17/03/2022 | Away | | | Won | 84 | v | 59 | Haves, Dave (32) | Irlam Steel | | |
| Week 24 | 24/03/2022 | Home | 64 | 1 | Won | 82 | v | 68 | Taylor, Mark (17) | Alford 'D' | | |
| Week 25 | 31/03/2022 | Away | | | Lost | 65 | v | 79 | Brown, Ryan (48) | Walkers 'B' | | |
| Week 26 | 21/04/2022 | Away | | | Lost | 53 | v | 86 | Owen, Keith (23) | Monks 'A' | | |
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