| Round | Date | H/A | Brk Max | Brks Over 30 | W/L | Pts | v | Pts | Away | Team | Brks Over 30 | Brk Max |
| Week 1 | 05/10/2021 | Home | | | Lost | 0 | v | 1 | Vernon, Mike (25) | Higher Ince Labour | | |
| Week 2 | 12/10/2021 | Away | | | Lost | 0 | v | 1 | Geldert, Bill (-5) | Haydock Conservative | | |
| Week 3 | 19/10/2021 | Home | | | Won | 1 | v | 0 | Briscoe, Craig (-22) | Golborne C.M.C. 'A' | | |
| Week 4 | 26/10/2021 | Away | | | Won | 1 | v | 0 | Bryce, Ian (-12) | Newton Social | | |
| Week 5 | 02/11/2021 | Home | | | Won | 1 | v | 0 | Davies, Mike (13) | Garswood Sports & Social | | |
| Week 6 | 09/11/2021 | Away | | | Lost | 0 | v | 1 | Higgens, Karl (-13) | Bryn Labour | | |
| Week 8 | 23/11/2021 | Home | | | Lost | 0 | v | 1 | Fanning, John (23) | Golborne C.M.C. 'B' | | |
| Week 9 | 07/12/2021 | Away | | | Lost | 0 | v | 1 | Bruen, Dennis (17) | Viaduct | | |
| Week 10 | 14/12/2021 | Home | | | Lost | 0 | v | 1 | Tyrer, Phil (-17) | Haydock Reading Room | | |
| Week 11 | 21/12/2021 | Away | | | Lost | 0 | v | 1 | | | | |
| Week 12 | 18/01/2022 | Away | | | Won | 1 | v | 0 | Jarret, Dave (1) | Higher Ince Labour | | |
| Week 13 | 25/01/2022 | Home | | | Lost | 0 | v | 1 | Geldert, Bill (-5) | Haydock Conservative | | |
| Week 14 | 08/02/2022 | Away | | | Lost | 0 | v | 1 | Leigh, David (6) | Golborne C.M.C. 'A' | | |
| Week 15 | 15/02/2022 | Home | | | Won | 1 | v | 0 | Chester, Mike (-36) | Newton Social | | |
| Week 16 | 22/02/2022 | Away | | | Lost | 0 | v | 1 | McKeegan, Anthony (21) | Garswood Sports & Social | | |
| Week 17 | 08/03/2022 | Home | | | Won | 1 | v | 0 | Witkiewicz, Steve (-19) | Bryn Labour | | |
| Week 18 | 15/03/2022 | Home | | | Lost | 0 | v | 1 | Cahill, Bernard (5) | Stubshaw Labour | | |
| Week 19 | 22/03/2022 | Away | | | Won | 1 | v | 0 | Wood, Adam (-17) | Golborne C.M.C. 'B' | | |
| Week 20 | 05/04/2022 | Home | | | Won | 1 | v | 0 | Moorhouse, John (13) | Viaduct | | |
| Week 21 | 12/04/2022 | Away | | | Won | 1 | v | 0 | Whittle, Nigel (5) | Haydock Reading Room | | |
| Week 22 | 19/04/2022 | Home | | | Lost | 0 | v | 1 | McClymont, Mark (9) | Newton Conservative | | |
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