| Round | Date | H/A | Brk Max | Brks Over 30 | W/L | Pts | v | Pts | Away | Team | Brks Over 30 | Brk Max |
| Week 1 | 05/10/2021 | Home | | | Lost | 0 | v | 1 | Hickey, Paul (20) | Higher Ince Labour | | |
| Week 3 | 19/10/2021 | Home | | | Won | 1 | v | 0 | Wingrove, Martin (-2) | Golborne C.M.C. 'A' | | |
| Week 4 | 26/10/2021 | Away | | | Lost | 0 | v | 1 | Canning, Lee (-5) | Newton Social | | |
| Week 5 | 02/11/2021 | Home | | | Won | 1 | v | 0 | Woodcock, Gary (25) | Garswood Sports & Social | | |
| Week 6 | 09/11/2021 | Away | | | Lost | 0 | v | 1 | Gore, Tommy (6) | Bryn Labour | | |
| Week 7 | 16/11/2021 | Away | | | Lost | 0 | v | 1 | Wilde, Mike (-2) | Stubshaw Labour | | |
| Week 8 | 23/11/2021 | Home | | | Won | 1 | v | 0 | Fanning, Stephen (14) | Golborne C.M.C. 'B' | | |
| Week 9 | 07/12/2021 | Away | | | Lost | 0 | v | 1 | Haselton, Eric (6) | Viaduct | | |
| Week 10 | 14/12/2021 | Home | | | Lost | 0 | v | 1 | Clancy, Damion (25) | Haydock Reading Room | | |
| Week 11 | 21/12/2021 | Away | | | Won | 1 | v | 0 | McClymont, Mark (9) | Newton Conservative | | |
| Week 12 | 18/01/2022 | Away | | | Won | 1 | v | 0 | Ellison, Paul (-18) | Higher Ince Labour | | |
| Week 13 | 25/01/2022 | Home | | | Won | 1 | v | 0 | Makin, Ray (-18) | Haydock Conservative | | |
| Week 14 | 08/02/2022 | Away | | | Lost | 0 | v | 1 | Briscoe, Craig (-22) | Golborne C.M.C. 'A' | | |
| Week 15 | 15/02/2022 | Home | | | Won | 1 | v | 0 | Canning, Lee (-5) | Newton Social | | |
| Week 16 | 22/02/2022 | Away | | | Won | 1 | v | 0 | Quinn, Steve (25) | Garswood Sports & Social | | |
| Week 17 | 08/03/2022 | Home | | | Won | 1 | v | 0 | Higgens, Karl (-13) | Bryn Labour | | |
| Week 18 | 15/03/2022 | Home | | | Won | 1 | v | 0 | Ryan, Neil (10) | Stubshaw Labour | | |
| Week 19 | 22/03/2022 | Away | | | Won | 1 | v | 0 | Twist, Mark (-19) | Golborne C.M.C. 'B' | | |
| Week 20 | 05/04/2022 | Home | | | Won | 1 | v | 0 | Blackburn, Brian (25) | Viaduct | | |
| Week 21 | 12/04/2022 | Away | | | Won | 1 | v | 0 | Rotherham, Darrell (-6) | Haydock Reading Room | | |
| Week 22 | 19/04/2022 | Home | | | Lost | 0 | v | 1 | Edge, Les (22) | Newton Conservative | | |
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